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    搜索结果包含 Al 的内容

    Jul 05,2023
    合成一类新型选择性TNIK抑制剂并评估其抗结直肠癌作用，PK研究通过AG真人国际(中国)官方官网进行
    The Traf2- and Nck-interacting protein kinase (TNIK) is a downstream signal protein of the Wnt/β-catenin pathway and has been thought of as a potential target for the treatment of colorectal cancer.
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    合成一类新型选择性TNIK抑制剂并评估其抗结直肠癌作用，PK研究通过AG真人国际(中国)官方官网进行
    Jul 05,2023
    用于治疗非酒精性脂肪性肝炎的PPARα/δ 双重激动剂的设计合成和生物学评价，PK研究、hERG研究和Ames试验通过AG真人国际(中国)官方官网进行
    Nonalcoholic steatohepatitis (NASH) is the advanced subtype of nonalcoholic fatty liver disease (NAFLD) and is becoming a severe global public health problem. PPARα/δ are regarded as potential therape
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    用于治疗非酒精性脂肪性肝炎的PPARα/δ 双重激动剂的设计合成和生物学评价，PK研究、hERG研究和Ames试验通过AG真人国际(中国)官方官网进行
    Jul 05,2023
    ARD-2585是一种口服有效的PROTAC雄激素受体降解剂，可用于治疗晚期前列腺癌。肝微粒体稳定性测定、血浆稳定性测定和hERG测定通过AG真人国际(中国)官方官网进行
    A PROTAC-based androgen receptor (AR) degrader is a bifunctional small molecule, consisting of an AR ligand that binds to AR protein, and a ligand that binds to and recruits an E3 ligase complex, teth
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    ARD-2585是一种口服有效的PROTAC雄激素受体降解剂，可用于治疗晚期前列腺癌。肝微粒体稳定性测定、血浆稳定性测定和hERG测定通过AG真人国际(中国)官方官网进行
    Jul 05,2023
    选择性小分子c-Myc降解剂可有效消退c-Myc过表达的肿瘤，表面等离子共振 (SPR) 实验通过AG真人国际(中国)官方官网进行
    Cancer is one of the leading causes of death worldwide. MYC oncogene is involved in the majority of human cancers and is often associated with poor outcomes. WBC100, a novel oral active molecule glue
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    选择性小分子c-Myc降解剂可有效消退c-Myc过表达的肿瘤，表面等离子共振 (SPR) 实验通过AG真人国际(中国)官方官网进行
    Jul 03,2023
    小核酸抗体偶联药物（AOC）的优势
    AOC解决目前小核酸药物仅能通过LNP(脂质纳米颗粒)、GalNac（N-乙酰半乳糖胺）递送系统靶向肝脏的问题，同时规避了目前ADC药物因为毒素偶然释放带来的风险。
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    小核酸抗体偶联药物（AOC）的优势
    Jun 29,2023
    一文了解小核酸抗体偶联药物(AOC)全球市场现状
    目前全球在研AOC的公司主要有：Avidity Biosesciences、Dyne Therapeutics、Tallac Therapeutics、Denali Therapeutics等。
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    一文了解小核酸抗体偶联药物(AOC)全球市场现状
    Jun 28,2023
    SAHA可有效恢复阿尔茨海默病模型的记忆能力，本研究中SAHA通过AG真人国际(中国)官方官网合成
    SAHA was synthesized by Medicilon and was given to mice as 50 mg/kg doses. Injections (10 mL/kg) were given intraperitoneally and were alternated daily between left and right sides of the abdomen. Chronic treatments of SAHA completely restored performance
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    SAHA可有效恢复阿尔茨海默病模型的记忆能力，本研究中SAHA通过AG真人国际(中国)官方官网合成
    Jun 28,2023
    TAK-243是一种有效的泛素激活酶小分子抑制剂，具有体内抗肿瘤功效，通过AG真人国际(中国)官方官网使用HCC70模型进行
    TAK-243 is a potent, mechanism-based small-molecule inhibitor of the ubiquitin activating enzyme (UAE), the primary mammalian E1 enzyme that regulates the ubiquitin conjugation cascade. TAK-243 has UAE-specific antitumor efficacy in vivo. Medicilon perfor
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    TAK-243是一种有效的泛素激活酶小分子抑制剂，具有体内抗肿瘤功效，通过AG真人国际(中国)官方官网使用HCC70模型进行
    Jun 28,2023
    法尼基转移酶抑制剂LNK-754单次口服后即可快速穿过血脑屏障，PK分析通过AG真人国际(中国)官方官网进行
    Pharmacokinetic studies revealed that after a single oral dose, the FTI (LNK-754) was cleared from plasma within 20 hours and could rapidly cross the blood-brain-barrier. Pharmacokinetic analysis was performed as a service provided by Medicilon.
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    法尼基转移酶抑制剂LNK-754单次口服后即可快速穿过血脑屏障，PK分析通过AG真人国际(中国)官方官网进行
    Jun 28,2023
    WYC-209可抑制恶性小鼠黑色素瘤肿瘤再生细胞增殖，SPR分析通过AG真人国际(中国)官方官网使用Biacore 8K设备进行
    The binding assay by surface plasmon resonance (SPR) analysis shows that WYC-209A and WYC-209B acid bind to RARs at nano-molar doses. SPR was carried out by Medicilon, using the Biacore 8K equipment.
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    WYC-209可抑制恶性小鼠黑色素瘤肿瘤再生细胞增殖，SPR分析通过AG真人国际(中国)官方官网使用Biacore 8K设备进行
    Jun 28,2023
    ARD-2128是一种PROTAC AR降解剂，具有出色的血浆和微粒体稳定性，体外稳定性和PK研究通过AG真人国际(中国)官方官网进行
    ARD-2128 has excellent plasma and microsomal stability in all the five species (Human, Mouse, Rat, Dog, and Monkey). The in vitro stability and pharmacokinetic (PK) studies were performed by Medicilon.
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    ARD-2128是一种PROTAC AR降解剂，具有出色的血浆和微粒体稳定性，体外稳定性和PK研究通过AG真人国际(中国)官方官网进行
    Jun 28,2023
    设计合成一系列DHODH抑制剂作为潜在的类风湿性关节炎治疗药物，PK研究通过AG真人国际(中国)官方官网进行
    Human dihydroorotate dehydrogenase (DHODH) is a viable target for the development of therapeutics to treat cancer and immunological diseases. Herein, researchers designed and synthesized a series of acrylamide-based novel DHODH inhibitors as potential rhe
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    设计合成一系列DHODH抑制剂作为潜在的类风湿性关节炎治疗药物，PK研究通过AG真人国际(中国)官方官网进行
    Jun 28,2023
    CAR-T疗法主要针对白血病与恶性淋巴瘤，此研究中构建沉默PD-1的shRNA载体质粒，测序后质粒的鉴定通过AG真人国际(中国)官方官网进行
    Chimeric antigen receptor T cells (CAR-T) immunotherapy has shown promising clinical results in the treatment of leukemia and lymphoma, but the effectiveness is limited for solid tumors. The shRNA vector plasmid that silences PD-1 and preparation of CAR i
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    CAR-T疗法主要针对白血病与恶性淋巴瘤，此研究中构建沉默PD-1的shRNA载体质粒，测序后质粒的鉴定通过AG真人国际(中国)官方官网进行
    Jun 28,2023
    TAK-931是一种高度特异性的CDC7抑制剂，具有抗肿瘤功效，体内药效研究通过AG真人国际(中国)官方官网进行
    In vivo efficacy studies in J558 allograft models in combination with anti-mPD-1, anti-mPD-L1, and anti-mCTLA-4 antibodies were performed at Medicilon.
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    TAK-931是一种高度特异性的CDC7抑制剂，具有抗肿瘤功效，体内药效研究通过AG真人国际(中国)官方官网进行
    Jun 28,2023
    GS-5801是一种有效的KDM5抑制剂，具有抗HBV活性，GS-5801通过AG真人国际(中国)官方官网合成
    GS-5801, a potent inhibitor of KDM5, has antiviral activity against HBV in a primary human hepatocytes infection model, with the cellular permeability, oral bioavailability. GS-5801 was synthesized by Medicilon.
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    GS-5801是一种有效的KDM5抑制剂，具有抗HBV活性，GS-5801通过AG真人国际(中国)官方官网合成
    Jun 28,2023
    QF-036是一种高效的HIV-1抑制剂，具有良好的和药代动力学特性，PK研究通过AG真人国际(中国)官方官网进行
    The favourable viral inhibitory activity and pharmacokinetic properties provide critical support for QF-036 as a promising anti-HIV therapeutic candidate. The pharmacokinetic studies were performed by Medicilon.
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    QF-036是一种高效的HIV-1抑制剂，具有良好的和药代动力学特性，PK研究通过AG真人国际(中国)官方官网进行
    Jun 28,2023
    设计合成一种新型选择性的口服有效苏氨酸酪氨酸激酶 (TTK) 抑制剂，PK研究均通过AG真人国际(中国)官方官网进行
    TTK inhibition is an attractive wide-spectrum strategy for cancer therapy. Researchers designed and synthesized a series of pyrido[2, 3-d]pyrimidin-7(8H)-ones as new selective orally bioavailable TTK inhibitors. All the pharmacokinetic studies were carrie
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    设计合成一种新型选择性的口服有效苏氨酸酪氨酸激酶 (TTK) 抑制剂，PK研究均通过AG真人国际(中国)官方官网进行
    Jun 28,2023
    TR-107是人类线粒体蛋白酶ClpP的有效激活剂，PK分析通过AG真人国际(中国)官方官网进行
    The pharmacokinetic properties of TR‐107 were compared with other known ClpP activators including ONC201 and ONC212. TR‐107 displayed excellent exposure and serum t1/2 after oral administration. Pharmacokinetic analysis were evalsuated for pharmacokinetic
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    TR-107是人类线粒体蛋白酶ClpP的有效激活剂，PK分析通过AG真人国际(中国)官方官网进行
    Jun 28,2023
    H11-HLE是一种工具分子，可用于研究Fc在介导免疫检查点治疗中的作用，具有抗肿瘤功效
    Immune checkpoint inhibition therapies have been used for multiple cancer research. H11-HLE is a tool molecule that allows the interrogation of the contribution of Fc in mediating immune checkpoint therapy. Half-life extended H11 (H11-HLE) induces potent
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    H11-HLE是一种工具分子，可用于研究Fc在介导免疫检查点治疗中的作用，具有抗肿瘤功效
    Jun 28,2023
    JND003是一种新型选择性ERRα激动剂，可缓解非酒精性脂肪肝和胰岛素抵抗，PK和组织分布测定通过AG真人国际(中国)官方官网进行
    JND003 is orally bioavailable and exhibits high grade of distribution in liver and abdominal adipose tissues. Pharmacokinetics (PK) and Tissue Distribution Assays of JND003 were performed at Medicilon.
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    JND003是一种新型选择性ERRα激动剂，可缓解非酒精性脂肪肝和胰岛素抵抗，PK和组织分布测定通过AG真人国际(中国)官方官网进行